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GIP and GLP-1 are incretin hormones mostly secreted by enteroendocrine K-cells in the duodenum and L-cells in the small intestine, respectively [40]

For example, if you started a GLP-1 in September 2024 with a BMI of 37, but in July 2026 you've lost weight and now have a BMI of 34, the prescriber should attest in the prior authorization request that you met the BMI criteria of 35 or over when the GLP-1 therapy started

Patients should confirm the current amount with the insurer and dispensing pharmacy rather than relying on a general estimate

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Restarting semaglutide after a break has been studied to some degree, and the results suggest that most people can successfully resume with comparable effects after a washout period